Chris Cornell, one of the most lauded and respected contemporary lead singers in rock music with his bands Soundgarden and Audioslave, killed himself Wednesday by hanging in a Detroit hotel room, according to the city's medical examiner. He was 52.

The Wayne County Medical Examiner's Office said Thursday it completed the preliminary autopsy on Cornell, but that "a full autopsy report has not yet been completed." A police spokesman told two Detroit newspapers that the singer was found with a band around his neck.

"His wife Vicky and family were shocked to learn of his sudden and unexpected passing, and they will be working closely with the medical examiner to determine the cause," Brian Bumbery, a representative for Cornell, said in a statement. "They would like to thank his fans for their continuous love and loyalty and ask that their privacy be respected at this time."

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Tributes to Cornell began pouring in on Twitter as news of his death spread.

With his powerful, nearly four-octave vocal range, Cornell was one of the leading voices of the 1990s grunge movement with Soundgarden, which emerged as one of the biggest bands out of Seattle's emerging music scene, joining the likes of Nirvana, Pearl Jam and Alice in Chains.

Formed in 1984 by Cornell, guitarist Kim Thayil and bassist Hiro Yamamoto, Soundgarden broke through on mainstream radio with the album "Superunknown," which debuted at No. 1 on the Billboard 200 and was nominated for a Grammy for Best Rock Record in 1995. It included hit singles "Spoonman," ''Fell on Black Days," ''Black Hole Sun," ''My Wave" and "The Day I Tried to Live."

Soundgarden disbanded in 1997 due to tensions in the band, and Cornell pursued a solo career. In 2001, he joined Audioslave, a supergroup that included former Rage Against the Machine members Tom Morello, Brad Wilk and Tim Commerford. Audioslave disbanded in 2007, but Cornell and Soundgarden reunited in 2012 and released the band's sixth studio album, "King Animal" in 2012.

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Cornell also collaborated with members of what would become Pearl Jam to form Temple of the Dog, which produced a self-titled album in 1991 in tribute to friend Andrew Wood, former frontman for Mother Love Bone.

Cornell, who provided the theme song to the James Bond film Casino Royale, released four solo studio albums and a solo live album.

In addition to his music, Cornell also became involved in philanthropy and started the Chris and Vicky Cornell Foundation to support children facing challenges, including homelessness, poverty, abuse and neglect.